Table 1:
AT-RvD1 and Dexamethasone treatment reduce apoptosis in submandibular glands
from NOD/ShiltJ mice (raw data). NOD/ShiltJ mice were systemically injected via tail vein
injections with the following treatments: (A) NaCl (0.9%),
(B) AT-RvD1 (0.01-0.1 mg/kg) and (C) dexamethasone (DEX; 8.25 mg/Kg) 2 times a
week for 14 weeks. At 18 weeks of age, submandibular glands were removed,
frozen, and sections from were fixed and evaluated by terminal deoxynucleotidyl transferase-mediated
dUTP-biotin nick-end labeling
(TUNEL). The results are from 3 biological replicates.
Raw data for TUNEL analysis.
Mean Intensity (Normalized values) |
||||||
Treatments |
n = 1 |
n = 2 |
n = 3 |
|||
NaC10.9% |
134.5468 |
(−2.083) |
17.159 |
(−0.584) |
1.2283 |
(−0.785) |
RvD10.1 mg/kg |
25.04571 |
(−0.492) |
2.5511 |
(−0.299) |
0.771 |
(−0.55) |
DEX 8.25 mg/kg |
7.404106 |
(−0.236) |
3.5235 |
(−0.741) |
5.4319 |
(−2.941) |
Positive |
25.40182 |
2.1055 |
36.426 |
|||
Negative |
6.902441 |
0.0217 |
0.0075 |
Positive and negative
rows indicate TUNEL experimental controls with and without DNase
I respectively as indicated in the manufacturer's instructions. Positive and
negative controls were performed in frozen mouse sub man dibular
gland sections from C57BL/6 mice.